Division I
Region 1: 1 Cle. St. Ignatius (11-1) vs. 3 Mentor (11-1) at Bedford Bearcat Stadium
Region 2: 1 Tol. Whitmer (12-0) vs. 2 Powell Olentangy Liberty (10-2) at Findlay Donnell Stadium
Region 3: 5 Pickerington North (10-2) vs. 3 Pickerington Central (11-1) at Cols. St. Francis DeSales Alumni Stadium
Region 4: 1 Cin. St. Xavier (11-1) vs. 2 Cin. Colerain (10-2) at Mason Dwire Field at Atrium Stadium
Division II
Region 5: 1 Akr. Archbishop Hoban (11-1) vs. 2 Barberton (12-0) at Green Memorial Stadium
Region 6: 1 Avon (12-0) vs. 3 Olmsted Falls (11-1) at North Ridgeville Ranger Stadium
Region 7: 5 New Albany (8-4) vs. 2 Massillon Washington (9-3) at Mansfield Senior Arlin Field
Region 8: 1 Cin. La Salle (10-2) vs. 2 Cin. Winton Woods (11-1) at Cin. Withrow Angus King Stadium
Division III
Region 9: 1 Canfield (12-0) vs. 6 Akr. St. Vincent-St. Mary (9-3) at Salem Reilly Stadium
Region 10: 1 Tol. Central Catholic (10-2) vs. 2 Bay Village Bay (12-0) at Sandusky Strobel Field, Cedar Point Stadium
Region 11: 5 Dresden Tri-Valley (11-1) vs. 3 Cols. Bishop Hartley (11-1) at Newark Paul “Hoss” Starr Stadium at White Field
Region 12: 1 Trotwood-Madison (12-0) vs. 7 Chaminade Julienne (9-3) at Riverside Stebbins Edmundson Stadium
Division IV
Region 13: 1 Steubenville (12-0) vs. 2 Perry (12-0) at Niles McKinley Bo Rein Stadium
Region 14: 5 Bellevue (9-3) vs. 2 Shelby (12-0) at Ashland Community Stadium
Region 15: 5 New Concord John Glenn (10-2) vs. 7 Duncan Falls Philo (9-3) at Zanesville Sulsberger Stadium
Region 16: 4 Clinton-Massie (11-1) vs. 2 Wyoming (12-0) at Lakota West Firebird Field
Division V
Region 17: 1 Canfield South Range (12-0) vs. 3 Sullivan Black River (11-1) at Canal Fulton Northwest Dr. Martin Smilek Stadium/Jim Schalmo Field
Region 18: 1 Pemberville Eastwood (12-0) vs. 2 Marion Pleasant (10-1) at Lima Senior Spartan Stadium
Region 19: 1 Wheelersburg (12-0) vs. 3 Johnstown-Monroe (10-2) at Chillicothe Herrnstein Stadium
Region 20: 5 West Jefferson (11-0) vs. 2 Madison (10-2) at Beavercreek Frank Zink Field at Miami Valley Hospital Stadium
Division VI
Region 21: 1 Rootstown (12-0) vs. 3 Kirtland (12-0) at Solon Stewart Field
Region 22: 1 Findlay Liberty-Benton (11-1) vs. 6 Jeromesville Hillsdale (9-3) at Tiffin Frost-Kalnow Stadium
Region 23: 1 Nelsonville-York (12-0) vs. 3 Coal Grove Dawson-Bryant (11-1) at Jackson Holzer Field at Alumni Stadium
Region 24: 4 Coldwater (9-3) vs. 2 Marion Local (12-0) at Sidney Memorial Stadium
Division VII
Region 25: 1 Dalton (12-0) vs. 2 Cuyahoga Heights (10-1) at North Canton Hoover Memorial Stadium
Region 26: 1 Norwalk St. Paul (12-0) vs. 3 Pandora-Gilboa (10-2) at Clyde Robert J. Bishop Jr. Stadium
Region 27: 1 Danville (11-1) vs. 6 Hannibal River (8-4) at Zanesville Maysville Athletic Complex
Region 28: 4 Minster (8-4) vs. 3 Delphos St. John’s (8-4) at Wapakoneta Harmon Field