The contract includes an immediate 15 percent pay raise.
Contract negotiations began in 2012. Mediated talks started in 2014. Pilots last November rejected another proposed contract.
Union president Capt. Jon Weaks says members thought the latest agreement was the right thing for them and their families. The association represents about 8,400 pilots.
Flight attendants at Southwest last month narrowly ratified a new contract.
Southwest has several flights out of the Dayton International Airport.
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