Her cause and manner of death have not been determined at this time.
Fire investigators are working to determine what sparked the blaze reported in 5400 block of West Third Street around 11:42 p.m. Thursday.
Trotwood Fire Deputy Chief Brandon Barnett said crews arrived on scene to find heavy smoke and flames.
No other people were in the house, and no additional injuries were reported.
The house did not have working smoke detectors. The residence also did not have gas or electric, Barnett said.
Fire crews from Trotwood, Dayton and Clayton all responded to the incident.
Trotwood fire investigators are continuing to look into the blaze.