The Pontiac rotated and split open, and the Nissan flipped onto its top and skidded to a top, deputies said.
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Both drivers suffered injuries that were not life-threatening.
A 1-year-old child riding in the Nissan was not injured, but was taken to a local hospital to be checked.
A 78-year-old man riding in the Pontiac had serious, life-threatening injuries, deputies said.
Deputies closed the intersection for the crash investigation.