The crash was reported around 9:10 p.m. in the 5000 block of North Hamburg Road, according to Indiana State Police.
The Cessna (tail number N761YZ left Kansas City, Missouri, and was headed to an airport in Frederick, Maryland. It is unclear what caused the plane to crash.
>> Judge: Embattled Carlisle crematorium may have solid defamation claims
Cincinnati Air Traffic Control reported a plane being tracked disappeared from radar in the area of the crash.
Witnesses reported the plane caught fire. Officers found the wreckage and firefighters extinguished the blaze.
Autopsies will be performed Monday by the Franklin County Coroner’s Office in Indiana. Their names won’t be released until the coroner’s office confirms their identifies and speaks to family.
>> 2-month-old baby boy found dead at Dayton home
The only survivor was a second dog that showed up at a nearby residence. It was taken to a local veterinarian to be treated for injuries, the state police said.
The Indiana State Police is conducting a joint investigation with the Federal Aviation Administration and the National Transportation Safety Board. The ISP said the investigation is ongoing and may take weeks to complete.
The Indiana State Police was initially assisted by numerous police and fire departments in Franklin County as well as the Franklin County Coroner's Office.
FIRST REPORT
A small airplane crashed Saturday near Hamburg Road in Franklin County, Indiana, resulting in three deaths according to Indiana State Highway Patrol and our partners at WCPO.
RELATED: See more trending stories on WHIO.com
Indiana State Highway Patrol reports the plane originated in Kansas City, Missouri and stopped in Columbus, Indiana to refuel, before taking off for its final destination of Maryland.
The plane was privately owned and ISP reports that three people were inside the plane at the time of the crash around 9 p.m. Saturday behind a home on Hamburg Road.
DOWNLOAD OUR FREE NEWS APPS FOR OUR LATEST BREAKING NEWS
Police are still working to identify the victims and the investigation is being handed over to the FAA. Police say the initial cause of the crash has been attributed to engine failure.
One dog also died in the crash, while a second dog survived and was evaluated by a veterinarian, according to our news partner WCPO-TV in Cincinnati.
We will continue to bring you the latest updates in this developing story.