Investigators are searching for Casei Jones, 32, and her four children; Cameron Bowers, 10; Preston Bowers, 5; Mercalli Jones, 2; and Aiyana Jones, 1.
Officials said they were last seen in the Ocala area in central Florida.
Investigators said Jones may be driving a 2017 Chrysler Pacifica with Florida tag 91SEJ.
Anyone with information regarding this case is asked to call 911 or the Marion County Sheriff's Office at 372-732-9111.
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