Brayan Rocchio doubled leading off the third and Kwan hit his second home run on the next pitch for a 4-1 lead. Kwan added run-scoring singles his next two times up to go 4 for 5.
Gavin Williams (1-0) allowed one run on three hits and two walks, striking out seven in five innings. Jakob Junis and Joey Cantillo both pitched two scoreless innings.
Jonathan Cannon (0-2) allowed six runs on seven hits and three walks in the loss, pitching 5 1/3 innings in his third start.
A rough month got worse when the White Sox put Korey Lee (left ankle) and Mike Tauchman (right hamstring strain) on the 10-day injured list before the game. Andrew Benintendi was put on the 10-day IL on Wednesday.
Key moment
Manzardo’s home run came after a shaky first inning from Williams, who settled down after giving up a single and a walk before throwing two wild pitches in falling behind 1-0.
Key stat
The Guardians beat Chicago 1-0 and 3-2 in the first two games despite having just three hits in each — something they hadn’t done since 1901 in back-to-back victories. The Rockies were the last to do it — 30 years ago.
Up next
Tanner Bibee (1-1, 6.52 ERA) starts for the Guardians on Friday in the first of three games against the visiting Royals. Davis Martin (0-1, 5.73) starts as the White Sox begin a six-game homestand on Friday with the first of three against the Red Sox.
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