The game was tied at 51-51 with under three minutes to play. La Salle, often not shooting until the final seconds of the shot clock, took control with an 8-1 run.
Dayton fell to 12-3 and 2-1 in the A-10. La Salle (5-8, 1-2) snapped a seven-game losing streak.
Charles Cooke led Dayton with 21 points. Jordan Price scored 17 for La Salle.
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