Makira Cook matched a career-high with 29 points to pace the Flyers, who moved to 18-3 overall and 9-0 in the A-10. The sophomore guard hit 13 of 15 shots from the field, including 3 of 4 attempts from 3-point range. Cook scored 29 against Wright State earlier this season.
Jenna Giacone added 12 points, Brynn Shoup-Hill had 10 points and Araion Bradshaw added nine points, seven rebounds and five assists.
The Flyers stormed out to a 23-6 first-quarter lead and led 43-13 at halftime.
Dayton had 14 steals and shot 47 percent (34-of-73). George Mason shot 28 percent (16-of-58) and committed 22 turnovers.
The Flyers return to action Wednesday on the road at Saint Louis. Dayton returns home Feb. 13 vs. VCU for a noon tip at UD Arena.